The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Identifieur interne : 000135 ( an2020/Analysis ); précédent : 000134; suivant : 000136The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Auteurs : Yan-Rong Guo [République populaire de Chine] ; Qing-Dong Cao [République populaire de Chine] ; Zhong-Si Hong [République populaire de Chine] ; Yuan-Yang Tan [République populaire de Chine] ; Shou-Deng Chen [République populaire de Chine] ; Hong-Jun Jin [République populaire de Chine] ; Kai-Sen Tan [Singapour] ; De-Yun Wang [Singapour] ; Yan Yan [République populaire de Chine]Source :
- Military Medical Research [ 2054-9369 ] ; 2020.
Abstract
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.
DOI: 10.1186/s40779-020-00240-0
PubMed: 32169119
Affiliations:
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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Infectious Disease, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Yuan Yang" sort="Tan, Yuan Yang" uniqKey="Tan Y" first="Yuan-Yang" last="Tan">Yuan-Yang Tan</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Shou Deng" sort="Chen, Shou Deng" uniqKey="Chen S" first="Shou-Deng" last="Chen">Shou-Deng Chen</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Hong Jun" sort="Jin, Hong Jun" uniqKey="Jin H" first="Hong-Jun" last="Jin">Hong-Jun Jin</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Kai Sen" sort="Tan, Kai Sen" uniqKey="Tan K" first="Kai-Sen" last="Tan">Kai-Sen Tan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Wang, De Yun" sort="Wang, De Yun" uniqKey="Wang D" first="De-Yun" last="Wang">De-Yun Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228, Singapore. entwdy@nus.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China. yanyan35@mail.sysu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Military Medical Research</title><idno type="eISSN">2054-9369</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Guo, Yan Rong" sort="Guo, Yan Rong" uniqKey="Guo Y" first="Yan-Rong" last="Guo">Yan-Rong Guo</name></noRegion><name sortKey="Cao, Qing Dong" sort="Cao, Qing Dong" uniqKey="Cao Q" first="Qing-Dong" last="Cao">Qing-Dong Cao</name><name sortKey="Chen, Shou Deng" sort="Chen, Shou Deng" uniqKey="Chen S" first="Shou-Deng" last="Chen">Shou-Deng Chen</name><name sortKey="Hong, Zhong Si" sort="Hong, Zhong Si" uniqKey="Hong Z" first="Zhong-Si" last="Hong">Zhong-Si Hong</name><name sortKey="Jin, Hong Jun" sort="Jin, Hong Jun" uniqKey="Jin H" first="Hong-Jun" last="Jin">Hong-Jun Jin</name><name sortKey="Tan, Yuan Yang" sort="Tan, Yuan Yang" uniqKey="Tan Y" first="Yuan-Yang" last="Tan">Yuan-Yang Tan</name><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name></country><country name="Singapour"><noRegion><name sortKey="Tan, Kai Sen" sort="Tan, Kai Sen" uniqKey="Tan K" first="Kai-Sen" last="Tan">Kai-Sen Tan</name></noRegion><name sortKey="Wang, De Yun" sort="Wang, De Yun" uniqKey="Wang D" first="De-Yun" last="Wang">De-Yun Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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